Selected HAMM Lab Publications:

Tanner, BC, Daniel, TL, and Regnier, M (2007).
Sarcomere Lattice Geometry Influences Cooperative Myosin Binding in Muscle. PLoS Comput Biol 3(7):e115.

Kreutziger KL, Gillis TE, Davis JP, Tikunova SB, Regnier M.
Influence of enhanced troponin C Ca2+ binding affinity on cooperative thin filament activation in rabbit skeletal muscle. J Physiol. 2007 Jun 21; [Epub ahead of print]

D. A. Martyn, L. Smith, K. L. Kreutziger, S. Xu, L. C. Yu, and M. Regnier (2007).
The Effects of Force Inhibition by Sodium Vanadate on Cross-Bridge Binding, Force Redevelopment, and Ca2+ Activation in Cardiac Muscle. Biophys. J. 92: 4379-4390.

Gillis, TE, Martyn, DA, Rivera, AJ, and Regnier, M (2007).
Investigation of thin filament near-neighbour regulatory unit interactions during force development in skinned cardiac and skeleta muscle.J Physiol 580(Pt 2):561-576.

Moreno-Gonzalez, A, Gillis, TE, Rivera, AJ, Chase, PB, Martyn, DA, and Regnier, M (2007).
Thin-filament regulation of force redevelopment kinetics in rabbit skeletal muscle fibres. J Physiol 579(Pt 2):313-26.

Shaffer, JF, Razumova, MV, Tu, A, Regnier, M, and Harris, SP (2007).
Myosin S2 is not required for effects of myosin binding protein-C on motility. FEBS Lett 581(7):1501-4.

Razumova MV, Shaffer JF, Tu A-Y, Flint GV, Regnier M, and Harris SP (2006).
Effect of the N-terminal domains of myosin binding protein-C in an in vitro motility assay. J Biol Chem 281: 35846-35854.

Bell MG, Lankford EB, Gonye GE, Ellis-Davies GC, Martyn DA, Regnier M, Barsotti RJ (2006).
Kinetics of cardiac thin-filament activation probed by fluorescence polarization of rhodamine-labeled troponin C in skinned guinea pig trabeculae. Biophys J. 90(2):531-43.

Clemmens, EW, Entezari, M, Martyn, DA, and Regnier, M (2005).
Different effects of cardiac vs. skeletal muscle regulatory proteins on in vitro measures of actin filament speed and force.
J Physiol 566(Pt 3):737-46.

Moreno-Gonzalez, A, Fredlund, J, and Regnier, M (2005).
Cardiac troponin C (TnC) and a site I skeletal TnC mutant alter Ca2+ versus crossbridge contribution to force in rabbit skeletal fibres.
J Physiol 562(Pt 3):873-84.

Adhikari, BB, Regnier, M, Rivera, AJ, Kreutziger, KL, and Martyn, DA (2004).
Cardiac length dependence of force and force redevelopment kinetics with altered cross-bridge cycling.
Biophys J 87(3):1784-94.

Martyn, DA, Adhikari, BB, Regnier, M, Gu, J, Xu, S, and Yu, LC (2004).
Response of equatorial x-ray reflections and stiffness to altered sarcomere length and myofilament lattice spacing in relaxed skinned cardiac muscle.
Biophys J 86(2):1002-11.

Regnier, M, Martin, H, Barsotti, RJ, Rivera, AJ, Martyn, DA, and Clemmens, E (2004).
Cross-Bridge versus Thin Filament Contributions to the Level and Rate of Force Development in Cardiac Muscle.
Biophys J 87(3):1815-24.

Regnier, M, Martin, H, Barsotti, RJ, Rivera, AJ, Martyn, DA, and Clemmens, E (2004).
Cross-bridge versus thin filament contributions to the level and rate of force development in cardiac muscle.
Biophys J 87(3):1815-24.

Gordon, AM, Rivera, AJ, Wang, CK, and Regnier, M (2003).
Cooperative activation of skeletal and cardiac muscle.
Adv Exp Med Biol 538:371-8; discussion 378-9.

Korte, FS, McDonald, KS, Harris, SP, and Moss, RL (2003).
Loaded shortening, power output, and rate of force redevelopment are increased with knockout of cardiac myosin binding protein-C.
Circ Res 93(8):752-8.

Kohler, J, Chen, Y, Brenner, B, Gordon, AM, Kraft, T, Martyn, DA, Regnier, M, Rivera, AJ, Wang, C, and Chase, PB (2003).
Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding.
Physiol Genomics 14(2):117-28.

Liang, B, Chen, Y, Wang, C, Luo, Z, Regnier, M, Gordon, AM, and Chase, PB (2003).
Ca2+ regulation of rabbit skeletal muscle thin filament sliding: role of cross-bridge number.
Biophys J 85(3):1775-86.

Martyn, DA, Chase, PB, Regnier, M, and Gordon, AM (2002).
A simple model with myofilament compliance predicts activation-dependent crossbridge kinetics in skinned skeletal fibers.
Biophys J 83(6):3425-34.

Regnier, M, Rivera, AJ, Wang, C, Bates, MA, Chase, PB, and Gordon, AM (2002).
Thin filament near-neighbour regulatory unit interactions affect rabbit skeletal muscle steady-state force-Ca(2+) relations.
J Physiol 540(Pt 2):485-97.

Gordon, AM, Regnier, M, and Homsher, E (2001).
Skeletal and cardiac muscle contractile activation: tropomyosin "rocks and rolls".
News Physiol Sci 16:49-55.

Martyn, DA, Regnier, M, Xu, D, and Gordon, AM (2001).
Ca2+ - and cross-bridge-dependent changes in N- and C-terminal structure of troponin C in rat cardiac muscle.
Biophys J 80(1):360-70.

Martyn, DA, and Gordon, AM (2001).
Influence of length on force and activation-dependent changes in troponin c structure in skinned cardiac and fast skeletal muscle.
Biophys J 80(6):2798-808.

Gordon, AM, Homsher, E, and Regnier, M (2000).
Regulation of contraction in striated muscle.
Physiol Rev 80(2):853-924.

Regnier, M, Rivera, AJ, Chen, Y, and Chase, PB (2000).
2-deoxy-ATP enhances contractility of rat cardiac muscle.
Circ Res 86(12):1211-7.

Martyn, DA, Freitag, CJ, Chase, PB, and Gordon, AM (1999).
Ca2+ and cross-bridge-induced changes in troponin C in skinned skeletal muscle fibers: effects of force inhibition.
Biophys J 76(3):1480-93.

Regnier, M, Chase, PB, and Martyn, DA (1999).
Contractile properties of rabbit psoas muscle fibres inhibited by beryllium fluoride.
J Muscle Res Cell Motil 20(4):425-32.

Regnier, M, Rivera, AJ, Chase, PB, Smillie, LB, and Sorenson, MM (1999).
Regulation of skeletal muscle tension redevelopment by troponin C constructs with different Ca2+ affinities.
Biophys J 76(5):2664-72.

Regnier, M, and Homsher, E (1998).
The effect of ATP analogs on posthydrolytic and force development steps in skinned skeletal muscle fibers.
Biophys J 74(6):3059-71.

Regnier, M, Lee, DM, and Homsher, E (1998).
ATP analogs and muscle contraction: mechanics and kinetics of nucleoside triphosphate binding and hydrolysis.
Biophys J 74(6):3044-58.

Regnier, M, Martyn, DA, and Chase, PB (1998).
Calcium regulation of tension redevelopment kinetics with 2-deoxy-ATP or low [ATP] in rabbit skeletal muscle.
Biophys J 74(4):2005-15.

Homsher, E, Lacktis, J, and Regnier, M (1997).
Strain-dependent modulation of phosphate transients in rabbit skeletal muscle fibers.
Biophys J 72(4):1780-91.

Gordon, AM, Qian, Y, Luo, Z, Wang, CK, Mondares, RL, and Martyn, DA (1997).
Characterization of troponin-C interactions in skinned barnacle muscle: comparison with troponin-C from rabbit striated muscle.
J Muscle Res Cell Motil 18(6):643-53.

Hancock, WO, Martyn, DA, Huntsman, LL, and Gordon, AM (1996).
Influence of Ca2+ on force redevelopment kinetics in skinned rat myocardium.
Biophys J 70(6):2819-29.

Regnier, M, Martyn, DA, and Chase, PB (1996).
Calmidazolium alters Ca2+ regulation of tension redevelopment rate in skinned skeletal muscle.
Biophys J 71(5):2786-94.

Regnier, M, Morris, C, and Homsher, E (1995).
Regulation of the cross-bridge transition from a weakly to strongly bound state in skinned rabbit muscle fibers.
Am J Physiol 269(6 Pt 1):C1532-9.

Martyn, DA, and Chase, PB (1995).
Faster force transient kinetics at submaximal Ca2+ activation of skinned psoas fibers from rabbit.
Biophys J 68(1):235-42.

Chase, PB, Martyn, DA, and Hannon, JD (1994).
Isometric force redevelopment of skinned muscle fibers from rabbit activated with and without Ca2+.
Biophys J 67(5):1994-2001.

Chase, PB, Martyn, DA, and Hannon, JD (1994).
Activation dependence and kinetics of force and stiffness inhibition by aluminiofluoride, a slowly dissociating analogue of inorganic phosphate, in chemically skinned fibres from rabbit psoas muscle.
J Muscle Res Cell Motil 15(2):119-29.

Martyn, DA, Chase, PB, Hannon, JD, Huntsman, LL, Kushmerick, MJ, and Gordon, AM (1994).
Unloaded shortening of skinned muscle fibers from rabbit activated with and without Ca2+.
Biophys J 67(5):1984-93.

Chase, PB, Martyn, DA, Kushmerick, MJ, and Gordon, AM (1993).
Effects of inorganic phosphate analogues on stiffness and unloaded shortening of skinned muscle fibres from rabbit.
J Physiol 460:231-46.

Hancock, WO, Martyn, DA, and Huntsman, LL (1993).
Ca2+ and segment length dependence of isometric force kinetics in intact ferret cardiac muscle.
Circ Res 73(4):603-11.

Hannon, JD, Chase, PB, Martyn, DA, Huntsman, LL, Kushmerick, MJ, and Gordon, AM (1993).
Calcium-independent activation of skeletal muscle fibers by a modified form of cardiac troponin C.
Biophys J 64(5):1632-7.

Martyn, DA, Coby, R, Huntsman, LL, and Gordon, AM (1993).
Force-calcium relations in skinned twitch and slow-tonic frog muscle fibres have similar sarcomere length dependencies.
J Muscle Res Cell Motil 14(1):65-75.

Hannon, JD, Martyn, DA, and Gordon, AM (1992).
Effects of cycling and rigor crossbridges on the conformation of cardiac troponin C.
Circ Res 71(4):984-91.